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Quality and training

Training and interpretation

Professor Keith Kerr discusses the interpretation of borderline
PD-L1 assay outcomes

Training tools

A range of information is available to assist with interpretative training:

PD-L1 e-trainer tool (sample)

  • Provided below is an example of the training offered by the PD-L1 e-trainer tool, designed to allow pathologists to understand the basic principles of PD-L1 scoring and interpretation.
  • Registration is required to access the full PD-L1 e-trainer tool; please contact your local AstraZeneca representative for more information on all current and future training opportunities.
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NSCLC PD-L1 e-trainer tool (sample)

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NSCLC PD-L1 e-trainer tool (sample)

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UC PD-L1 e-trainer tool (sample)

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UC PD-L1 e-trainer tool (sample)

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Quality assurance

All procedures for verification or validation must be documented in a standard operating procedure. Factors for consideration for quality assurance purposes include:1

Controls

External quality assurance

  • EQA for PD-L1 can highlight whether or not an assay is performing in line with expectations and highlight any potential issues with staining that may lead to false-positive or false-negative results.1
  • The following links provide useful information about EQA schemes:

  • EQA requires continuous participation to:1

  • Ring studies can be used to compare the reproducibility of results between laboratories.2

Professor Keith Kerr discusses the need to properly validate laboratory developed tests (LDTs)

REFERENCES

  1. Cree IA, et al. Histopathology 2016;69:177–186.
  2. Thunnissen E, et al. J Clin Pathol 2011;64:884–892.

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